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 Hypertensive Nephropathy

What is Hypertensive Nephropathy?

What causes Hypertensive Nephropathy?

What are symptoms of Hypertensive Nephropathy?

What is the diagnosis of Hypertensive Nephropathy?

What is the treatment of Hypertensive Nephropathy?

Healthy diet for Hypertensive Nephropathy

What is the prognosis of Hypertensive Nephropathy?

What is Hypertensive Nephropathy?

Hypertensive Nephropathy is a kidney disease caused by years of high blood pressure. Generally, primary hypertension tends to happen when people are at 25 to 45 years old, but symptoms of kidney damages caused by hypertension appears when people are at 40 to 60 years old. In fact, if high blood pressure is under control timely and effectively, hypertension hardly causes kidney damages. In this case, as long as hypertension patients control their blood pressure actively, it is more likely for them to keep far away from hypertensive nephropathy.

What are causes of Hypertensive Nephropathy?

Kidney itself is such a organ which is surrounded by blood capillary. Kidney is used to filter toxins, prevents protein and blood cells, etc from leaking from blood vessels. Hypertension makes the increase of blood pressure in the vessels which makes protein leak from vessels. The leaked protein will do damages on filtering system of kidneys. And this condition will be vicious circle. The long-term damage is irreversible and kidney compensation is going to increase.

The incidence rate of kidney damage due to hypertension is related with the severity and duration of hypertension. Other factors, such as gender, race, diabetes, hyperlipidemia and hyperuricemia, will further aggravate kidney damages.

What are symptoms of Hypertensive Nephropathy?

Having a comprehensive knowledge about symptoms of Hypertensive Nephropathy contributes to the general diagnosis about if hypertension patients are experiencing kidney damages. Well, let’s have a look at common symptoms of Hypertensive Nephropathy.

1. Frequent urination at night

Renal tubule has the function of reabsorption. However, long period of high blood pressure will damage renal tubule. Normally, we do not go to urinate at night, but with damaged renal tubule, we may urinate for at least 3 times at night.

2. Changed urine color

Hypertensive nephropathy patients’ urine may become dark orange, tea-color and even red.

3. Protein urine

Usually the more protein in urine, the more serious the hypertensive nephropathy is.

4. Edema

Edema is a common symptom of kidney disease. In early stage of Hypertensive Nephropathy, edema usually appears at our eyelids, face and ankles, but with the progression of kidney damage, it can occur in our whole body.

5. Hyperlipemia

6. Hypoproteinemia

Due to lots of protein leakage from the urine, patients may experience hypoproteinemia.

The above are some common symptoms of Hypertensive Nephropathy and because of different illness conditions, some patients may have some rare signs.

What are the tests for Hypertensive Nephropathy?

1. Uric Albumin Test: due to persistent high impact to renal capillary, hypertension will damage kidneys. In this condition, hypertensive nephropathy patients usually have albumin in urine.

2. β2 microglobulin in urine: tests on β2 microglobulin in urine is the sensitive index of measuring Glomerular Filtration Rate and reabsorption function of renal tubule. For hypertensive nephropathy patients, β2 microglobulin in their urine increases. And it will reduce when high blood pressure is under control.

3. Sediments: sediments is helpful for diagnosing whether there are too many malformed red blood cells in urine and if there are, it always indicates kidney problems.

4. Urinary N-acetyl-B-D-glucosaminidase: hypertensive Nephropathy patients without any treatments always have elevated urinary N-acetyl-B-D-glucosaminidase, so measuring urinary N-acetyl-B-D-glucosaminidase contributes to diagnosing hypertensive nephropathy.

What is the treatment of hypertensive nephropathy?

Oral medicine for Hypertensive Nephropathy

In some country, especially in some western countries, Hypertensive Nephropathy patients usually take some hypotensor like ACEI, ARB, Beta-blockers, Calcium channel blockers and diuretics to control high blood pressure. And then patients take some oral medicines which aims to control symptoms like high creatinine, protein and edema to control kidney damages. These western oral medicines has a quick efficacy on controlling kidney symptoms. However, once patients reduce the dose of stop taking medicines, kidney disease easily relapse immediately.

Traditional Chinese Medicine

As a traditional treatment, Chinese Medicines already have been proven to be effective in lowering high blood pressure. What’s more, Chinese medicine can improve residual kidney function and repair kidney damage with its four functions, including anti-inflammation, anti-coagulation, extension to blood vessels as well as degrading extracellular matrixes, which are of great importance for patients’ recovery. Theoretically, in early stage of hypertensive nephropathy, patients are likely to avoid kidney failure through specific chinese medicines which can repair kidney damages. However, patients should know they can not recover simply with Traditional Chinese Medicines due to its slow effects.


Immunotherapy combines Micro-Chinese Medicine Osmotherapy with western oral medicines. As we know, western medicines work fast but fail to prevent further kidney damages radically while Chinese medicines can stop kidney damage from root but work slowly. Based on the respective advantages of these two treatments, immunotherapy is created.

In immunotherapy, oral medicines are first used to control high blood pressure and other symptoms. When illness conditions get stable, Micro-Chinese Medicine Osmotherapy is applied to regulate patients’ internal condition. Micro-Chinese Medicine Osmotherapy can not only activate damaged renal function cells but increase bloodstream flowing into kidneys. With more and more blood flowing into kidneys, GFR will increase to some extent. Also, with activated renal intrinsic cells, kidney function is improved.

In immunotherapy, it mainly uses Micro-Chinese Medicine for patients’ recovery. Chinese medicines work slowly, so it takes patients a long time to achieve the expecting purpose. When hypertensive nephropathy advances to a certain stage, it is urgent for patients to stop and repair kidney damages. In view of this, Chinese Medicines are used externally to directly work on the location of kidney. In this way, treatment effects can be found in a relatively short time.

Immunotherapy combines the advantages of western medicine and Chinese medicines in which Hypertensive Nephropathy can be controlled radically within limited time.

Healthy diet for Hypertensive Nephropathy

Having a healthy diet is important in managing symptoms and slows down the progression of Hypertensive Nephropathy.

1. Low salt diet.

Patients should consume salt within 6g per day. Low salt diet can not only control high blood pressure but also contribute to remitting edema.

2. Balance protein intake

Patients should consume proper protein according to their illness conditions. Without obvious kidney damages, protein intake should be limited in 50g per day while patients with obvious serum creatinine and blood urea nitrogen should decrease protein intake to 20g to 40g per day.

3. Drink tea properly

Tea polyphenols are of great importance for the metabolism of fat. And drinking tea can soften blood vessels

4. High vitamin diet

Ingesting adequate vitamin, particularly vitamin B, helps to regulate our metabolism.

What is the prognosis of Hypertensive Nephropathy?

Hypertensive nephropathy has two types-benign nephrosclerosis and malignant nephrosclerosis, so there is a difference of prognosis.

1. Benign nephrosclerosis

Benign nephrosclerosis rarely leads to kidney failure. It is said that patients are able to live more than 5 years since the onset of disease.

2. Malignant nephrosclerosis

Malignant nephroslerosis usually has a poor prognosis. Patients with this condition will have decreased renal reserve and may not cope very well with acute illness and surgical procedures.


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